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Learn · Neuroplastic symptoms

Conditions with a neuroplastic contribution, A to Z.

Real symptoms, normal tests, treatments that did not work as expected. For many diagnoses, the brain is part of the story. Here is what that means, condition by condition.

Neuroplastic symptoms are real physical symptoms, including pain, fatigue, dizziness, gut trouble and dozens of others, that are generated by learned pathways in the brain and nervous system rather than by ongoing damage or disease in the body. They are not imaginary and not a sign of weakness, and because the brain can change, they can change too.

The Association for the Treatment of Neuroplastic Symptoms publishes an index of hundreds of diagnoses with a note on how much a neuroplastic process may contribute to each. The pages below cover every entry in the 2026 index where that contribution is described. Each one explains the condition, summarises the index’s position in plain language, points to the research on PubMed, and describes the approach that addresses the brain’s role. None of them is a diagnosis: structural and organ causes always need to be checked first.

New to the idea? Start with central sensitization or the three types of pain.

382 conditions

Whole-body, fatigue and labels

Head, face and headache

Spine, back and neck

Muscles, joints and limbs

Nerves, sensation and neurological

Digestive

Pelvic, urinary and reproductive

Heart, breathing and autonomic

Eyes, ears and balance

Skin, hair and mouth

Hormones, immune, infection and metabolic

Mental health and sleep

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These articles are for general education and are not medical advice, and they do not diagnose or treat any condition. Persistent symptoms deserve a proper medical assessment to rule out disease or injury before a neuroplastic explanation is considered. If your symptoms are new, changing, or come with red-flag signs such as fever, unexplained weight loss, numbness or weakness, chest pain, or loss of bladder or bowel control, see a clinician promptly.